Embryos requireculture media in the laboratory to optimise their development by supporting metabolic and physiological phases before implantation. Improvement of embryo culture has contributed significantly to the increase in the overall success rates in assisted reproductive technology (ART).
EmbryoGen® and BlastGen™ are new sequential culture media. Fertilised and cleavage-stage embryos (zygote to day three) are cultured with EmbryoGen®, followed by the culture to the blastocyst stage with BlastGen™. For the embryos cultured with this system, BlastGen™ is the recommended medium for embryo transfer.
EmbryoGen® and BlastGen™ are suitable for all patients and are especially recommended for people who have experienced recurrent biochemical pregnancy loss, miscarriage, recurrent implantation failures or unexplained infertility. EmbryoGen® and BlastGen™ are culture media that have been developed with the addition of the cytokine Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF). GM-CSF is a protein expressed in the female reproductive tract, and is upregulated throughout embryo development. Research has shown that an addition of 2ng/ml of GM-CSF to culture media improved embryo growth and development.